Yeast RNA-Binding Protein Nab3 Regulates Genes Involved in Nitrogen Metabolism | Zendy

Jonathan Merran | Zendy; Jeffry L. Corden | Zendy

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Yeast RNA-Binding Protein Nab3 Regulates Genes Involved in Nitrogen Metabolism

Author(s) -

Jonathan Merran,

Jeffry L. Corden

Publication year - 2017

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00154-17

Subject(s) - biology , polyadenylation , rna , saccharomyces cerevisiae , rna polymerase ii , terminator (solar) , rna binding protein , exosome complex , catabolite repression , microbiology and biotechnology , gene , non coding rna , gene expression , biochemistry , promoter , mutant , ionosphere , physics , astronomy

Termination ofSaccharomyces cerevisiae RNA polymerase II (Pol II) transcripts occurs through two alternative pathways. Termination of mRNAs is coupled to cleavage and polyadenylation while noncoding transcripts are terminated through the Nrd1-Nab3-Sen1 (NNS) pathway in a process that is linked to RNA degradation by the nuclear exosome. Some mRNA transcripts are also attenuated through premature termination directed by the NNS complex. In this paper we present the results of nuclear depletion of the NNS component Nab3. As expected, many noncoding RNAs fail to terminate properly. In addition, we observe that nitrogen catabolite-repressed genes are upregulated by Nab3 depletion.

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