Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation | Zendy

Ora Haimov | Zendy; Urmila Sehrawat | Zendy; Ana Tamarkin-Ben Harush | Zendy; Anat Bahat | Zendy; Anna Uzonyi | Zendy; Alexander Will | Zendy; Hiroyuki Hiraishi | Zendy; Katsura Asano | Zendy; Rivka Dikstein | Zendy

Open Access

Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation

Author(s) -

Ora Haimov,

Urmila Sehrawat,

Ana Tamarkin-Ben Harush,

Anat Bahat,

Anna Uzonyi,

Alexander Will,

Hiroyuki Hiraishi,

Katsura Asano,

Rivka Dikstein

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00139-18

Subject(s) - eif4e , eukaryotic initiation factor , initiation factor , eukaryotic translation , biology , eif4a1 , eif2 , eukaryotic translation initiation factor 4 gamma , microbiology and biotechnology , translation (biology) , messenger rna , genetics , gene

Translation initiation of most mRNAs involves m7G-cap binding, ribosomal scanning, and AUG selection. Initiation from an m7G-cap-proximal AUG can be bypassed resulting in leaky scanning, except for mRNAs bearing thet ranslationi nitiator ofs hort 5′u ntranslated region (TISU) element.

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