Open AccessEWSR1-FLI1 Activation of the Cancer/Testis Antigen FATE1 Promotes Ewing Sarcoma Survival
Author(s) -
Zachary R. Gallegos,
Patrick Taus,
Zane A. Gibbs,
Kathleen McGlynn,
Nicholas C. Gomez,
Ian J. Davis,
Angelique W. Whitehurst
Publication year - 2019
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00138-19
Subject(s) - biology , fli1 , sarcoma , cancer research , transcription factor , microbiology and biotechnology , gene , genetics , pathology , medicine
Ewing sarcoma is characterized by a pathognomonic chromosomal translocation that generates the EWSR1-FLI1 chimeric transcription factor. The transcriptional targets of EWSR1-FLI1 that are essential for tumorigenicity are incompletely defined.
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