Open AccessRB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression
Author(s) -
Aren E. Marshall,
Michael V. Roes,
Daniel Thompsen Passos,
Megan C. DeWeerd,
Andrea C. Chaikovsky,
Julien Sage,
Christopher J. Howlett,
Frederick A. Dick
Publication year - 2019
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00105-19
Subject(s) - biology , retinoblastoma , genome instability , dna damage , carcinogenesis , dna repair , mutation , cancer , retinoblastoma protein , cancer research , cancer cell , homologous recombination , mutant , genetics , microbiology and biotechnology , cell cycle , dna , gene
Proliferative control in cancer cells is frequently disrupted by mutations in the retinoblastoma protein (RB) pathway. Intriguingly,RB1 mutations can arise late in tumorigenesis in cancer cells whose RB pathway is already compromised by another mutation. In this study, we present evidence for increased DNA damage and instability in cancer cells with RB pathway defects whenRB1 mutations are induced.
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