The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation | Zendy

Paul Kwangho Kwon | Zendy; HyoMin Kim | Zendy; Sung Wook Kim | Zendy; Byunghee Kang | Zendy; Hee Yi | Zendy; HyunOk Ku | Zendy; TaeYoung Roh | Zendy; KyongTai Kim | Zendy

Open Access

The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation

Author(s) -

Paul Kwangho Kwon,

HyoMin Kim,

Sung Wook Kim,

Byunghee Kang,

Hee Yi,

HyunOk Ku,

TaeYoung Roh,

KyongTai Kim

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00101-19

Subject(s) - biology , motif (music) , binding site , oscillation (cell signaling) , gene , microbiology and biotechnology , genetics , biophysics , physics , acoustics

The D site-binding protein (Dbp) supports the rhythmic transcription of downstream genes, in part by displaying high-amplitude cycling of its own transcripts compared to other circadian-clock genes. However, the underlying mechanism remains elusive. Here, we demonstrated that the poly(C) motif within theDbp proximal promoter, in addition to an E-box element, provoked transcriptional activation.

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