NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging | Zendy

Marta Andreia de Ribeiro Pinho | Zendy; Joana Catarina Macedo | Zendy; Elsa Logarinho | Zendy; Paulo S. Pereira | Zendy

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NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging

Author(s) -

Marta Andreia de Ribeiro Pinho,

Joana Catarina Macedo,

Elsa Logarinho,

Paulo S. Pereira

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00099-19

Subject(s) - nucleolus , fibrillarin , ribosome biogenesis , biology , psychological repression , nucleolin , microbiology and biotechnology , senescence , nucleolus organizer region , cell growth , cellular senescence , ribosome , rna , genetics , phenotype , gene expression , nucleus , gene

The nucleolus is a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis, complex processes that require hundreds of proteins and factors. Alterations in nucleolar morphology and protein content have been linked to the control of cell proliferation and stress responses and, recently, further implicated in cell senescence and ageing.

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