Delineating the Structural Blueprint of the Pre-mRNA 3′-End Processing Machinery | Zendy

Kehui Xiang | Zendy; Liang Tong | Zendy; James L. Manley | Zendy

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Delineating the Structural Blueprint of the Pre-mRNA 3′-End Processing Machinery

Author(s) -

Kehui Xiang,

Liang Tong,

James L. Manley

Publication year - 2014

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00084-14

Subject(s) - polyadenylation , biology , cleavage and polyadenylation specificity factor , blueprint , messenger rna , cleavage factor , cleavage stimulation factor , directionality , computational biology , microbiology and biotechnology , precursor mrna , post transcriptional modification , cleavage (geology) , genetics , gene , rna splicing , rna , rna binding protein , engineering , paleontology , fracture (geology) , mechanical engineering

Processing of mRNA precursors (pre-mRNAs) by polyadenylation is an essential step in gene expression. Polyadenylation consists of two steps, cleavage and poly(A) synthesis, and requires multiple cis elements in the pre-mRNA and a megadalton protein complex bearing the two essential enzymatic activities. While genetic and biochemical studies remain the major approaches in characterizing these factors, structural biology has emerged during the past decade to help understand the molecular assembly and mechanistic details of the process. With structural information about more proteins and higher-order complexes becoming available, we are coming closer to obtaining a structural blueprint of the polyadenylation machinery that explains both how this complex functions and how it is regulated and connected to other cellular processes.

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