CKAP4 Regulates Cell Migration via the Interaction with and Recycling of Integrin | Zendy

Yoshihito Osugi | Zendy; Katsumi Fumoto | Zendy; Akira Kikuchi | Zendy

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CKAP4 Regulates Cell Migration via the Interaction with and Recycling of Integrin

Author(s) -

Yoshihito Osugi,

Katsumi Fumoto,

Akira Kikuchi

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00073-19

Subject(s) - sorting nexin , integrin , microbiology and biotechnology , biology , gene knockdown , integrin, beta 6 , internalization , endoplasmic reticulum , cell adhesion , cell migration , collagen receptor , fibronectin , integrin alpha m , cell , endosome , biochemistry , intracellular , extracellular matrix , gene

Cytoskeleton-associated protein 4 (CKAP4) is an endoplasmic reticulum protein that is also present in the cell surface membrane, where it acts as a receptor for Dickkopf1 (DKK1). In this study, we found that CKAP4 interacts with β1 integrin and controls the recycling of α5β1 integrin independently of DKK1. In S2-CP8 cells, knockdown of CKAP4 but not DKK1 enlarged the size of cell adhesion sites and enhanced cell adhesion to fibronectin, resulting in decreased cell migration.

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