Slfn2 Regulates Type I Interferon Responses by Modulating the NF-κB Pathway | Zendy

Mariafausta Fischietti | Zendy; Ahmet Arslan | Zendy; Antonella Sassano | Zendy; Diana Saleiro | Zendy; Beata Majchrzak-Kita | Zendy; Kazumi Ebine | Zendy; Hidayatullah G. Munshi | Zendy; Eleanor N. Fish | Zendy; Leonidas C. Platanias | Zendy

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Slfn2 Regulates Type I Interferon Responses by Modulating the NF-κB Pathway

Author(s) -

Mariafausta Fischietti,

Ahmet Arslan,

Antonella Sassano,

Diana Saleiro,

Beata Majchrzak-Kita,

Kazumi Ebine,

Hidayatullah G. Munshi,

Eleanor N. Fish,

Leonidas C. Platanias

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00053-18

Subject(s) - biology , interferon , transcription factor , nfkb1 , signal transduction , protein subunit , interferon type i , nf κb , gene , microbiology and biotechnology , interferon regulatory factors , regulation of gene expression , transcription (linguistics) , irf1 , genetics , linguistics , philosophy

Although members of the Slfn family have been implicated in the regulation of type I interferon (IFN) responses, the mechanisms by which they mediate their effects remain unknown. In the present study, we provide evidence that targeted disruption of theSlfn2 gene leads to increased transcription of IFN-stimulated genes (ISGs) and enhanced type I IFN-mediated antiviral responses.

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