Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis | Zendy

Pilar Liceras-Boillos | Zendy; David Jimeno | Zendy; Rósula GarcíaNavas | Zendy; L. Francisco LorenzoMartín | Zendy; Mauricio Menacho-Márquez | Zendy; Carmen Segrelles | Zendy; Carmela Gómez | Zendy; Nuria Calzada | Zendy; Rocío FuentesMateos | Zendy; Jesús M. Paramio | Zendy; Xosé R. Bustelo | Zendy; Fernando C. Baltanás | Zendy; Eugenio Santos | Zendy

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Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis

Author(s) -

Pilar Liceras-Boillos,

David Jimeno,

Rósula GarcíaNavas,

L. Francisco LorenzoMartín,

Mauricio Menacho-Márquez,

Carmen Segrelles,

Carmela Gómez,

Nuria Calzada,

Rocío FuentesMateos,

Jesús M. Paramio,

Xosé R. Bustelo,

Fernando C. Baltanás,

Eugenio Santos

Publication year - 2018

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00049-18

Subject(s) - biology , carcinogenesis , homeostasis , dermis , dmba , keratinocyte , hair follicle , cancer research , endocrinology , microbiology and biotechnology , medicine , cancer , biochemistry , anatomy , genetics , in vitro

Using Sos1 knockout (Sos1-KO), Sos2-KO, and Sos1/2 double-knockout (Sos1/2-DKO) mice, we assessed the functional role of Sos1 and Sos2 in skin homeostasis under physiological and/or pathological conditions. Sos1 depletion resulted in significant alterations of skin homeostasis, including reduced keratinocyte proliferation, altered hair follicle and blood vessel integrity in dermis, and reduced adipose tissue in hypodermis.

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