Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex | Zendy

David McClellan | Zendy; Mattie J. Casey | Zendy; Diana Bareyan | Zendy; Helena Lucente | Zendy; Christopher Ours | Zendy; Matthew Velinder | Zendy; Jason Singer | Zendy; Mehraju Din Lone | Zendy; Wenxiang Sun | Zendy; Yunuen Coria | Zendy; Clinton C. Mason | Zendy; Michael E. Engel | Zendy

Open Access

Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex

Author(s) -

David McClellan,

Mattie J. Casey,

Diana Bareyan,

Helena Lucente,

Christopher Ours,

Matthew Velinder,

Jason Singer,

Mehraju Din Lone,

Wenxiang Sun,

Yunuen Coria,

Clinton C. Mason,

Michael E. Engel

Publication year - 2019

Publication title -

molecular and cellular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.14

H-Index - 327

eISSN - 1067-8824

pISSN - 0270-7306

DOI - 10.1128/mcb.00020-19

Subject(s) - biology , demethylase , microbiology and biotechnology , histone , transcription factor , repressor , histone deacetylase , chromatin immunoprecipitation , genetics , gene expression , promoter , gene

Growth factor independence 1B (GFI1B) coordinates assembly of transcriptional repressor complexes comprised of corepressors and histone-modifying enzymes to control gene expression programs governing lineage allocation in hematopoiesis. Enforced expression of GFI1B in K562 erythroleukemia cells favors erythroid over megakaryocytic differentiation, providing a platform to define molecular determinants of binary fate decisions triggered by GFI1B.

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