Open AccessUnexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption
Author(s) -
Yan Zhang,
Liting Zhao,
Naining Wang,
Jing Li,
Fang He,
Xu Li,
Shufang Wu
Publication year - 2019
Publication title -
molecular and cellular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.14
H-Index - 327
eISSN - 1067-8824
pISSN - 0270-7306
DOI - 10.1128/mcb.00012-19
Subject(s) - osteoclast , bone resorption , osteoblast , matrix gla protein , microbiology and biotechnology , biology , medicine , endocrinology , chemistry , biochemistry , receptor , in vitro , kidney disease , hyperphosphatemia
Matrix Gla protein (MGP) is an extracellular protein responsible for inhibiting mineralization. MGP inhibits osteoblast mineralization and bone formation by regulating the deposition of bone matrix.
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