Open AccessLocal Rather than Global H3K27me3 Dynamics Are Associated with Differential Gene Expression in Verticillium dahliae
Author(s) -
Holger Kramer,
Michael Seidl,
Bart P.H.J. Thomma,
David E. Cook
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.03566-21
Subject(s) - biology , chromatin immunoprecipitation , epigenetics , chromatin , histone , genetics , gene , chromatin remodeling , regulation of gene expression , gene expression , verticillium , transcriptional regulation , transcription factor , microbiology and biotechnology , computational biology , promoter , botany
In many organisms, including filamentous fungi, epigenetic mechanisms that involve chemical and physical modifications of DNA without changing the genetic sequence have been implicated in transcriptional responses upon developmental or environmental cues. In fungi, facultative heterochromatin that can decondense to allow transcription in response to developmental changes or environmental stimuli is characterized by the trimethylation of lysine 27 on histone H3 (H3K27me3), and H3K27me3 has been implicated in transcriptional regulation, although the precise mechanisms and functions remain enigmatic.