Open AccessThe Odilorhabdin Antibiotic Biosynthetic Cluster and Acetyltransferase Self-Resistance Locus Are Niche and Species Specific
Author(s) -
Anne Lanois-Nouri,
Lucile Pantel,
Jun Fu,
Jessica Houard,
Jean-Claude Ogier,
Yury S. Polikanov,
Emilie Racine,
Hailong Wang,
Sophie Gaudriault,
Alain Givaudan,
Maxime Gualtiéri
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02826-21
Subject(s) - biology , antibiotic resistance , gene , microbiology and biotechnology , genetics , bacteria
Odilorhabdins (ODLs) constitute a novel antibiotic family with promising properties for treating problematic multidrug-resistant Gram-negative bacterial infections. ODLs are 10-mer linear cationic peptides inhibiting bacterial translation by binding to the small subunit of the ribosome.