Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo | Zendy

Dina A. Moustafa | Zendy; Ashley Wallace | Zendy; Danniel Zamora | Zendy; Seth M. Daly | Zendy; Carolyn R. Sturge | Zendy; Christine Pybus | Zendy; Bruce L. Geller | Zendy; Joanna B. Goldberg | Zendy; David E. Greenberg | Zendy

Open Access

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Author(s) -

Dina A. Moustafa,

Ashley Wallace,

Danniel Zamora,

Seth M. Daly,

Carolyn R. Sturge,

Christine Pybus,

Bruce L. Geller,

Joanna B. Goldberg,

David E. Greenberg

Publication year - 2021

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.02411-20

Subject(s) - morpholino , in vivo , pseudomonas aeruginosa , in vitro , multiple drug resistance , chemistry , conjugated system , peptide , microbiology and biotechnology , biology , biochemistry , bacteria , antibiotics , zebrafish , genetics , gene , polymer , organic chemistry

Numerous Gram-negative bacteria are becoming increasingly resistant to multiple, if not all, classes of existing antibiotics. Multidrug-resistant Pseudomonas aeruginosa bacteria are a major cause of health care-associated infections in a variety of clinical settings, endangering patients who are immunocompromised or those who suffer from chronic infections, such as people with cystic fibrosis (CF).

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