Open AccessComplement Receptor 3 Mediates HIV-1 Transcytosis across an Intact Cervical Epithelial Cell Barrier: New Insight into HIV Transmission in Women
Author(s) -
Christopher J. Day,
Rachael L. Hardison,
Belinda L. Spillings,
Jessica Poole,
Joseph A. Jurcisek,
Johnson Mak,
Michael P. Jennings,
Jennifer Edwards
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02177-21
Subject(s) - transcytosis , human immunodeficiency virus (hiv) , epithelium , female reproductive tract , immunology , receptor , virology , transmission (telecommunications) , biology , microbiology and biotechnology , medicine , uterus , endocytosis , pathology , electrical engineering , engineering
In women, the lower female reproductive tract is the primary site for HIV infection. How HIV traverses the epithelium to infect CD4 T cells in the submucosa is ill-defined.