Should Pneumococcal Vaccines Eliminate Nasopharyngeal Colonization? | Zendy

Larry S. McDaniel | Zendy; Edwin Swiatlo | Zendy

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Should Pneumococcal Vaccines Eliminate Nasopharyngeal Colonization?

Author(s) -

Larry S. McDaniel,

Edwin Swiatlo

Publication year - 2016

Publication title -

mbio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.562

H-Index - 121

eISSN - 2161-2129

pISSN - 2150-7511

DOI - 10.1128/mbio.00545-16

Subject(s) - streptococcus pneumoniae , pneumococcal disease , pneumococcal infections , pathogen , human pathogen , pneumococcal conjugate vaccine , virology , microbiology and biotechnology , medicine , immunology , biology , bacteria , antibiotics , genetics

Streptococcus pneumoniae remains an important human pathogen. For more than 100 years, there have been vaccine efforts to prevent pneumococcal infection. The pneumococcal conjugate vaccines have significantly reduced invasive disease. However, these vaccines have changed pneumococcal ecology within the human nasopharynx. We suggest that elimination of the pneumococcus from the human nasopharynx can have consequences that should be considered as the next generation of pneumococcal vaccines is developed.

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