Open AccessIdentification of Two New HLA-A*1101-Restricted Tax Epitopes Recognized by Cytotoxic T Lymphocytes in an Adult T-Cell Leukemia Patient after Hematopoietic Stem Cell Transplantation
Author(s) -
Nanae Harashima,
Ryuji Tanosaki,
Yukiko Shimizu,
Ken Kurihara,
Tohru Masuda,
Jun Okamura,
Mari Kannagi
Publication year - 2005
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.79.15.10088-10092.2005
Subject(s) - biology , cytotoxic t cell , human leukocyte antigen , epitope , hematopoietic stem cell transplantation , immunology , transplantation , stem cell , leukemia , haematopoiesis , cancer research , virology , antigen , genetics , medicine , in vitro
We previously reported that Tax-specific CD8(+) cytotoxic T lymphocytes (CTLs), directed to single epitopes restricted by HLA-A2 or A24, expanded in vitro and in vivo in peripheral blood mononuclear cells (PBMC) from some adult T-cell leukemia (ATL) patients after but not before allogeneic hematopoietic stem cell transplantation (HSCT). Here, we demonstrated similar Tax-specific CTL expansion in PBMC from another post-HSCT ATL patient without HLA-A2 or A24, whose CTLs equally recognized two newly identified epitopes, Tax88-96 and Tax272-280, restricted by HLA-A11, suggesting that these immunodominant Tax epitopes are present in the ATL patient in vivo.