Open AccessInflammatory Cytokines Inhibit Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene Transcription in In Vitro-Infected Endothelial Cells
Author(s) -
Steven G. Milligan,
Mairi Robinson,
Elizabeth O’Donnell,
David J. Blackbourn
Publication year - 2004
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.78.5.2591-2596.2004
Subject(s) - lytic cycle , biology , kaposi's sarcoma associated herpesvirus , cytokine , pathogenesis , virology , gammaherpesvirinae , sarcoma , in vitro , gene , proinflammatory cytokine , immunology , herpesviridae , cancer research , virus , inflammation , viral disease , pathology , genetics , medicine
The response of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) to inflammatory cytokine treatment of experimentally infected endothelial cells was investigated. The cytokines inhibited spontaneous KSHV lytic gene expression but not the level of infection. The data suggest that if inflammatory cytokines present in KS lesions contribute to KSHV pathogenesis, they do so in part by promoting latent KSHV infection of the endothelial cells.