Open AccessThe Virion Host Shutoff Protein of Herpes Simplex Virus Type 1 Has RNA Degradation Activity in Primary Neurons
Author(s) -
Stephanie S. Strand,
Tambryn K. Vanheyningen,
David A. Leib
Publication year - 2004
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.78.15.8400-8403.2004
Subject(s) - biology , virology , herpes simplex virus , host (biology) , virus , rna , genetics , gene
The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.