Expression of the Mouse Hepatitis Virus Receptor by Central Nervous System Microglia | Zendy

Chandran Ramakrishna | Zendy; Cornelia C. Bergmann | Zendy; Kathryn V. Holmes | Zendy; Stephen A. Stohlman | Zendy

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Expression of the Mouse Hepatitis Virus Receptor by Central Nervous System Microglia

Author(s) -

Chandran Ramakrishna,

Cornelia C. Bergmann,

Kathryn V. Holmes,

Stephen A. Stohlman

Publication year - 2004

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.78.14.7828-7832.2004

Subject(s) - biology , microglia , receptor , receptor expression , virus , central nervous system , virology , immunology , immune system , mouse hepatitis virus , interferon , inflammation , neuroscience , medicine , biochemistry , disease , covid-19 , infectious disease (medical specialty)

Detection of the mouse hepatitis virus receptor within the central nervous system (CNS) has been elusive. Receptor expression on microglia was reduced during acute infection and restored following immune-mediated virus control. Receptor down regulation was independent of neutrophils, NK cells, gamma interferon, or perforin. Infection of mice devoid of distinct inflammatory cells revealed CD4(+) T cells as the major cell type influencing receptor expression by microglia. In addition to demonstrating receptor expression on CNS resident cells, these data suggest that transient receptor down regulation on microglia aids in establishing persistence in the CNS by assisting virus infection of other glial cell types.

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