Open AccessA Novel Antiviral Intervention Results in More Accurate Assessment of Human Immunodeficiency Virus Type 1 Replication Dynamics and T-Cell Decay In Vivo
Author(s) -
Martin Markowitz,
Michael J. Louie,
Arlene Hurley,
Eugene Sun,
Michele Di Mascio,
Alan S. Perelson,
David D. Ho
Publication year - 2003
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.77.8.5037-5038.2003
Subject(s) - biology , in vivo , viral replication , virology , replication (statistics) , human immunodeficiency virus (hiv) , virus , potency , in vitro , genetics
Mathematical models provide an understanding of in vivo replication kinetics of human immunodeficiency virus type 1 (HIV-1). With a novel intervention designed for increased potency, we have more accurately deduced the half-lives of virus-producing CD4(+) T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication.