Open AccessBaseline Susceptibility of Primary Human Immunodeficiency Virus Type 1 to Entry Inhibitors
Author(s) -
Béatrice Labrosse,
JeanLouis Labernardière,
Elisabeth Dam,
Virginie Trouplin,
Katharina Skrabal,
François Clavel,
Fabrizio Mammano
Publication year - 2003
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.77.2.1610-1613.2003
Subject(s) - biology , virology , chemokine receptor , human immunodeficiency virus (hiv) , virus , viral entry , cxcr4 , chemokine , receptor , chemokine receptor ccr5 , immunology , viral replication , genetics
Human immunodeficiency virus type 1 plasma viruses from 29 entry inhibitor-naive patients were characterized for their susceptibilities to T-20, AMD3100, and RANTES. A strikingly wide range of susceptibilities to T-20 was observed that was influenced by coreceptor usage but not by the susceptibilities of the viruses to inhibitors that target the chemokine receptors or by polymorphisms in the gp41 N helix.