Open AccessParameters Driving the Selection of Nelfinavir-Resistant Human Immunodeficiency Virus Type 1 Variants
Author(s) -
Virginie Perrin,
Fabrizio Mammano
Publication year - 2003
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.77.18.10172-10175.2003
Subject(s) - biology , nelfinavir , infectivity , mutant , virology , mutation , resistance (ecology) , selection (genetic algorithm) , virus , genetics , gene , ecology , viral load , artificial intelligence , antiretroviral therapy , computer science
We investigated the parameters driving nelfinavir resistance, along the D30N and L90M evolutionary pathways. The advantage of the D30N mutant was mostly due to its resistance level, while the L90M mutation allowed preservation of infectivity coupled with minimal resistance. Emergence of secondary mutations further increased the selective advantage of viruses harboring D30N.