Open AccessCross-Reactivity of HLA-B * 1801-Restricted T-Lymphocyte Clones with Target Cells Expressing Variants of the Human Cytomegalovirus 72kDa-IE1 Protein
Author(s) -
Virginie Prod’homme,
Christelle Retière,
Ralitza Valtcheva,
Marc Bonneville,
MarieMartine Hallet
Publication year - 2003
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.77.12.7139-7142.2003
Subject(s) - biology , epitope , recombinant dna , virology , cytolysis , human leukocyte antigen , microbiology and biotechnology , cytomegalovirus , human cytomegalovirus , herpesviridae , virus , gene , genetics , in vitro , antigen , cytotoxic t cell , viral disease
The impact of natural polymorphism in a cytomegalovirus-dominant HLA-B(*)1801-restricted epitope, IE1(199-206), on the specific responses of T-cell clones was assessed by measuring their cytolytic activity against target cells expressing mutated recombinant IE1 proteins. Our results suggest an in vivo selection of T lymphocytes that cross-react with multiple IE1 variants.