Open AccessB7 Costimulation Plays an Important Role in Protection from Herpes Simplex Virus Type 2-Mediated Pathology
Author(s) -
Lydia G. Thebeau,
Lynda A. Morrison
Publication year - 2002
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.76.5.2563-2566.2002
Subject(s) - biology , herpes simplex virus , virology , simplexvirus , virus , immunology , herpesviridae , viral disease
We have used mice lacking both B7-1 and B7-2 costimulation molecules (B7KO) to investigate the effects of B7 costimulation on herpes simplex virus type 2 (HSV-2) pathogenesis. B7KO mice infected intravaginally with virulent HSV-2 showed more severe genital and neurologic disease and higher mortality rates than their wild-type counterparts. These results suggest that B7 costimulation molecules play an important role in the development of primary immune responses protective against HSV-2.