Open AccessRegression of a Murine Gammaherpesvirus 68-Positive B-Cell Lymphoma Mediated by CD4 T Lymphocytes
Author(s) -
Kevin A. Robertson,
Edward J. Usherwood,
Anthony Nash
Publication year - 2001
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.75.7.3480-3482.2001
Subject(s) - biology , lymphoma , immunohistochemistry , cancer research , t lymphocyte , adoptive cell transfer , immunology , t cell , microbiology and biotechnology , antigen , immune system
Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T lymphocytes were most effective in preventing tumor formation, and immunohistochemistry highlighted populations of CD4 T cells in regressing tumors.