Open AccessInfection and Activation of Monocytes by Marburg and Ebola Viruses
Author(s) -
Ute Ströher,
Elmar West,
Harald Bugany,
HansDieter Klenk,
Hans-Joachim Schnittler,
Heinz Feldmann
Publication year - 2001
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.75.22.11025-11033.2001
Subject(s) - ebola virus , biology , marburg virus , virology , proinflammatory cytokine , filoviridae , chemokine , virus , tumor necrosis factor alpha , monocyte , ebolavirus , immunology , microbiology and biotechnology , immune system , inflammation , viral disease , paramyxoviridae
In this study we investigated the effects of Marburg virus and Ebola virus (species Zaire and Reston) infections on freshly isolated suspended monocytes in comparison to adherent macrophages under culture conditions. Our data showed that monocytes are permissive for both filoviruses. As is the case in macrophages, infection resulted in the activation of monocytes which was largely independent of virus replication. The activation was triggered similarly by Marburg and Ebola viruses, species Zaire and Reston, as indicated by the release of the proinflammatory cytokines interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and IL-6 as well as the chemokines IL-8 and gro-alpha. Our data suggest that infected monocytes may play an important role in the spread of filoviruses and in the pathogenesis of filoviral hemorrhagic disease.