Open AccessPlasmacytoid Dendritic Cells Are Highly Susceptible to Human Immunodeficiency Virus Type 1 Infection and Release Infectious Virus
Author(s) -
Steven Patterson,
Aaron Rae,
Nicola Hockey,
Jill Gilmour,
Frances Gotch
Publication year - 2001
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.75.14.6710-6713.2001
Subject(s) - biology , virology , virus , antibody dependent enhancement , dc sign , c type lectin , macrophage , dendritic cell , immunology , lectin , viral replication , immune system , in vitro , biochemistry
Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage than a lymphotropic strain of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.