Open AccessHuman Immunodeficiency Virus Type 1-Specific Immunity after Genetic Immunization Is Enhanced by Modification of Gag and Pol Expression
Author(s) -
Yue Huang,
Wing-Pui Kong,
Gary J. Nabel
Publication year - 2001
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.75.10.4947-4951.2001
Subject(s) - biology , virology , group specific antigen , fusion protein , immunity , virus , cytotoxic t cell , antibody , immunization , immune system , immunology , genetics , gene , in vitro , recombinant dna
Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial Pol responses. This fusion protein may be useful for AIDS vaccines.