Open AccessFunctional Reconstitution of Thymopoiesis after Human Immunodeficiency Virus Infection
Author(s) -
Scott G. Kitchen,
M. Scott Killian,
Janis V. Giorgi,
Jerome A. Zack
Publication year - 2000
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.74.6.2943-2948.2000
Subject(s) - biology , thymocyte , severe combined immunodeficiency , immunology , virology , immune system , common variable immunodeficiency , virus , lentivirus , genetic enhancement , immunodeficiency , gene , cd8 , viral disease , genetics , antibody
We have utilized combination antiretroviral therapy following human immunodeficiency virus type 1-induced human CD4+ thymocyte depletion in the SCID-hu mouse to examine the immune competence of reconstituting thymocytes which appear following administration of combination therapy. These cells express a normal distribution of T-cell receptor variable gene families and are responsive to costimulatory signals. These results suggest that normal thymic function may be restored following antiretroviral treatment.