Open AccessHerpesvirus mRNAs Are Sorted for Export via Crm1-Dependent and -Independent Pathways
Author(s) -
Tarik M. Soliman,
Saul Silverstein
Publication year - 2000
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.74.6.2814-2825.2000
Subject(s) - biology , nuclear export signal , virology , genetics , computational biology , microbiology and biotechnology , rna , gene
Cellular pre-mRNA splicing is inhibited by ICP27, a herpes simplex virus regulatory protein, resulting in the shutoff of host protein synthesis. Here we reveal that ICP27 also mediates the export of some virus RNAs via a Crm1-dependent pathway and present evidence that independent domains are required for these functions. Sorting of some viral mRNAs for nuclear export requires Crm1, while other virus mRNAs are exported via another pathway.