Open AccessHuman Immunodeficiency Virus Type 1 Coreceptor Preferences Determine Target T-Cell Depletion and Cellular Tropism in Human Lymphoid Tissue
Author(s) -
JeanCharles Grivel,
Michael L. Penn,
Daniel A. Eckstein,
Birgit Schramm,
Roberto F. Speck,
Nancy W. Abbey,
Brian Herndier,
Leonid Margolis,
Mark A. Goldsmith
Publication year - 2000
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.74.11.5347-5351.2000
Subject(s) - biology , tropism , virology , tissue tropism , cxcr4 , virus , ex vivo , lymphatic system , in vitro , immunology , genetics , immune system , chemokine
The present study sought to determine how usage of coreceptors by human immunodeficiency virus type 1 dictates cell tropism and depletion of CD4+ T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor-expressing CD4+ lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.