Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy | Zendy

Graham S. Ogg | Zendy; Xia Jin | Zendy; Sebastian Bonhoeffer | Zendy; Paul Moss | Zendy; Martin A. Nowak | Zendy; Simon Monard | Zendy; Jeremy Segal | Zendy; Yaming Cao | Zendy; Sarah Rowland–Jones | Zendy; Arlene Hurley | Zendy; Martin Markowitz | Zendy; David D. Ho | Zendy; Andrew J. McMichael | Zendy; Douglas F. Nixon | Zendy

Open Access

Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy

Author(s) -

Graham S. Ogg,

Xia Jin,

Sebastian Bonhoeffer,

Paul Moss,

Martin A. Nowak,

Simon Monard,

Jeremy Segal,

Yaming Cao,

Sarah Rowland–Jones,

Arlene Hurley,

Martin Markowitz,

David D. Ho,

Andrew J. McMichael,

Douglas F. Nixon

Publication year - 1999

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.73.1.797-800.1999

Subject(s) - ctl* , biology , viremia , cytotoxic t cell , effector , virology , immunology , antiretroviral therapy , human immunodeficiency virus (hiv) , virus , viral load , immune system , cd8 , in vitro , genetics

Little is known of the changes in human immunodeficiency virus type 1 (HIV-1)-specific effector cytotoxic T lymphocytes (CTL) after potent antiretroviral therapy. Using HLA/peptide tetrameric complexes, we show that after starting treatment, there are early rapid fluctuations in the HIV-1-specific CTL response which last 1 to 2 weeks. These fluctuations are followed by an exponential decay (median half-life, 45 days) of HIV-1-specific CTL which continues while viremia remains undetectable. These data have implications for the immunological control of drug-resistant virus.

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