The rapid spread of recombinants during a natural in vitro infection with two human immunodeficiency virus type 1 strains | Zendy

Takeo Kuwata | Zendy; Y Miyazaki | Zendy; Tatsuhiko Igarashi | Zendy; Jun Takehisa | Zendy; Masanori Hayami | Zendy

Open Access

The rapid spread of recombinants during a natural in vitro infection with two human immunodeficiency virus type 1 strains

Author(s) -

Takeo Kuwata,

Y Miyazaki,

Tatsuhiko Igarashi,

Jun Takehisa,

Masanori Hayami

Publication year - 1997

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.71.9.7088-7091.1997

Subject(s) - biology , virology , virus , population , lentivirus , in vitro , human immunodeficiency virus (hiv) , viral disease , genetics , demography , sociology

We quantified a population of recombinants in a natural in vitro infection, using wild-type viruses without any pressure. It was found that recombinants emerged early after infection and constituted more than 20% of the whole proviral population 15 days after infection. Furthermore, recombinants were isolated as infectious viruses by simple limiting dilution. These results imply that, in addition to the high mutation rate of human immunodeficiency virus type 1 (HIV-1), recombination among HIV-1 strains plays a significant part in the development of the high diversity of HIV-1.

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