Defective viral DNA in Epstein-Barr virus-associated oral hairy leukoplakia | Zendy

Donna Patton | Zendy; Pamela S. Shirley | Zendy; Nancy RaabTraub | Zendy; Lionel Resnick | Zendy; John W. Sixbey | Zendy

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Defective viral DNA in Epstein-Barr virus-associated oral hairy leukoplakia

Author(s) -

Donna Patton,

Pamela S. Shirley,

Nancy RaabTraub,

Lionel Resnick,

John W. Sixbey

Publication year - 1990

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.64.1.397-400.1990

Subject(s) - biology , dna , virology , virus , polymerase chain reaction , epstein–barr virus , microbiology and biotechnology , genome instability , genome , dna polymerase , gene , genetics , dna damage

Defective Epstein-Barr virus (EBV) has a deleted and rearranged genome (termed het DNA) that disrupts latency and induces standard EBV to replicate in vitro. We used the polymerase chain reaction to detect, in 2 of 10 patient samples, the junction of abnormally juxtaposed EBV DNA fragments BamHI W and Z, a genomic rearrangement responsible for the biologic activity of het DNA. By sequence analysis, the junction in wild-type defective DNA appears to be similar but not identical to the recombination in the DNA of laboratory strain P3HR-1. The presence of this marker for het DNA in the epithelial lesions of two patients suggests a role for defective EBV in a human pathologic process.

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