Role of the 3' long open reading frame region of bovine leukemia virus in the maintenance of cell transformation | Zendy

R. Kettmann | Zendy; Y. Cleuter | Zendy; D. Grégoire | Zendy; A. Burny | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Role of the 3' long open reading frame region of bovine leukemia virus in the maintenance of cell transformation

Author(s) -

R. Kettmann,

Y. Cleuter,

D. Grégoire,

A. Burny

Publication year - 1985

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.54.3.899-901.1985

Subject(s) - biology , open reading frame , virology , bovine leukemia virus , leukemia , polyadenylation , clone (java method) , virus , transformation (genetics) , microbiology and biotechnology , viral transformation , rna , vector (molecular biology) , gene , genetics , peptide sequence , recombinant dna

Viral RNA expression was studied by dot blot hybridization with polyadenylated RNAs extracted from a bovine (YR-1) and an ovine (YR-2) tumor cell clone. Both clones were derived from in vivo bovine leukemia virus-induced tumors. The probes used were either the bovine leukemia virus information or only the long open reading frame sequences. No viral RNA corresponding to the bovine leukemia virus long open reading frame region was detected in YR-2, and a very limited amount of bovine leukemia virus messages was unraveled in YR-1. These results strongly suggest that viral expression, even in the long open reading frame region, is not required to maintain transformation of at least some tumor cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research