Open AccessHLA B*5701-Positive Long-Term Nonprogressors/Elite Controllers Are Not Distinguished from Progressors by the Clonal Composition of HIV-Specific CD8 + T Cells
Author(s) -
Daniel Mendoza,
Cassandra Royce,
Laura E. Ruff,
David R. Ambrozak,
Máire F. Quigley,
Thurston H. Y. Dang,
Vanessa Venturi,
David A. Price,
Daniel C. Douek,
Stephen A. Migueles,
Mark Connors
Publication year - 2012
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.06982-11
Subject(s) - biology , human leukocyte antigen , cd8 , immunology , cytotoxic t cell , virology , t cell receptor , epitope , hla b antigens , t cell , immune system , genetics , antigen , in vitro
To better understand the qualitative features of effective human immunodeficiency virus (HIV)-specific immunity, we examined the TCR clonal composition of CD8+ T cells recognizing conserved HIV p24-derived epitopes in HLA-B*5701-positive long-term nonprogressors/elite controllers (LTNP/EC) and HLA-matched progressors. Both groups displayed oligoclonal HLA-B5701-restricted p24-specific CD8+ T-cell responses with similar levels of diversity and few public clonotypes. Thus, HIV-specific CD8+ T-cell responses in LTNP/EC are not differentiated from those of progressors on the basis of clonal diversity or TCR sharing.
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