Open AccessCross-Species Transmission of Simian Foamy Virus to Humans in Rural Gabon, Central Africa
Author(s) -
Augustin MouingaOndémé,
Mélanie Caron,
Dieudonné Nkoghe,
Paul Telfer,
Preston A. Marx,
Ali Saı̈b,
Eric M. Leroy,
JeanPaul Gonzalez,
Antoine Gessain,
Mirdad Kazanji
Publication year - 2011
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.06016-11
Subject(s) - biology , virology , simian , integrase , transmission (telecommunications) , gorilla , virus , antibody , simian immunodeficiency virus , nested polymerase chain reaction , polymerase chain reaction , gene , genetics , human immunodeficiency virus (hiv) , paleontology , electrical engineering , engineering
In order to characterize simian foamy retroviruses (SFVs) in wild-born nonhuman primates (NHPs) in Gabon and to investigate cross-species transmission to humans, we obtained 497 NHP samples, composed of 286 blood and 211 tissue (bush meat) samples. Anti-SFV antibodies were found in 31 of 286 plasma samples (10.5%). The integrase gene sequence was found in 38/497 samples, including both blood and tissue samples, with novel SFVs in severalCercopithecus species. Of the 78 humans, mostly hunters, who had been bitten or scratched by NHPs, 19 were SFV seropositive, with 15 cases confirmed by PCR. All but one were infected with ape SFV. We thus found novel SFV strains in NHPs in Gabon and high cross-species transmission of SFVs from gorilla bites.
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