Open AccessCrystal Structure of Marburg Virus VP24
Author(s) -
Adrianna P. P. Zhang,
Zachary A. Bornholdt,
Dafna M. Abelson,
Erica Ollmann Saphire
Publication year - 2014
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.03565-13
Subject(s) - marburg virus , ebola virus , ebolavirus , virology , filoviridae , biology , viral life cycle , virus , viral disease , viral replication , paramyxoviridae
The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not. The crystal structure of Marburg virus VP24, presented here, reveals that although the core is similar between the viral genera, Marburg VP24 is distinguished by a projecting β-shelf and an alternate conformation of the N-terminal polypeptide.
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