Canine Distemper Virus Associated with a Lethal Outbreak in Monkeys Can Readily Adapt To Use Human Receptors | Zendy

Kouji Sakai | Zendy; Tomoki Yoshikawa | Zendy; Fumio Seki | Zendy; Shuetsu Fukushi | Zendy; Maino Tahara | Zendy; Noriyo Nagata | Zendy; Yasushi Ami | Zendy; Tetsuya Mizutani | Zendy; Ichiro Kurane | Zendy; Ryoji Yamaguchi | Zendy; Hideki Hasegawa | Zendy; Masayuki Saijo | Zendy; Katsuhiro Komase | Zendy; Shigeru Morikawa | Zendy; Makoto Takeda | Zendy

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Canine Distemper Virus Associated with a Lethal Outbreak in Monkeys Can Readily Adapt To Use Human Receptors

Author(s) -

Kouji Sakai,

Tomoki Yoshikawa,

Fumio Seki,

Shuetsu Fukushi,

Maino Tahara,

Noriyo Nagata,

Yasushi Ami,

Tetsuya Mizutani,

Ichiro Kurane,

Ryoji Yamaguchi,

Hideki Hasegawa,

Masayuki Saijo,

Katsuhiro Komase,

Shigeru Morikawa,

Makoto Takeda

Publication year - 2013

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.03479-12

Subject(s) - canine distemper , biology , virology , virus , hemagglutinin (influenza) , receptor , outbreak , immune system , mononegavirales , paramyxoviridae , immunology , viral disease , genetics

A canine distemper virus (CDV) strain, CYN07-dV, associated with a lethal outbreak in monkeys, used human signaling lymphocyte activation molecule as a receptor only poorly but readily adapted to use it following a P541S substitution in the hemagglutinin protein. Since CYN07-dV had an intrinsic ability to use human nectin-4, the adapted virus became able to use both human immune and epithelial cell receptors, as well as monkey and canine ones, suggesting that CDV can potentially infect humans.

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