Requirement for Fc Effector Mechanisms in the APOBEC3/Rfv3-Dependent Neutralizing Antibody Response | Zendy

Kalani Halemano | Zendy; Bradley S. Barrett | Zendy; Karl J. Heilman | Zendy; Thomas E. Morrison | Zendy; Mario L. Santiago | Zendy

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Requirement for Fc Effector Mechanisms in the APOBEC3/Rfv3-Dependent Neutralizing Antibody Response

Author(s) -

Kalani Halemano,

Bradley S. Barrett,

Karl J. Heilman,

Thomas E. Morrison,

Mario L. Santiago

Publication year - 2015

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.03399-14

Subject(s) - biology , virology , neutralizing antibody , neutralization , antibody , effector , polyclonal antibodies , antiserum , receptor , retrovirus , immune system , antibody dependent cell mediated cytotoxicity , immunology , virus , monoclonal antibody , genetics

Antiretroviral neutralizing antibody (NAb) responses are often evaluated in the absence of Fc-dependent immune effectors. In murine Friend retrovirus infection, Apobec3/Rfv3 promotes a potent polyclonal NAb response. Here, we show that the Apobec3/Rfv3-dependent NAb response correlated with virus-specific IgG2 titers and that the in vivo neutralization potency of Apobec3/Rfv3-resistant antisera was dependent on activating Fcγ receptors but not complement. The data strengthen retroviral vaccine strategies aimed at eliciting NAbs that activate specific Fcγ receptors.

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