Dissecting the Molecular Mechanisms of the Tropism of Varicella-Zoster Virus for Human T Cells | Zendy

Nandini Sen | Zendy; Ann M. Arvin | Zendy

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Dissecting the Molecular Mechanisms of the Tropism of Varicella-Zoster Virus for Human T Cells

Author(s) -

Nandini Sen,

Ann M. Arvin

Publication year - 2016

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.03375-14

Subject(s) - tropism , biology , varicella zoster virus , virology , virus , tissue tropism , viral entry , cell , t cell , homing (biology) , microbiology and biotechnology , viral replication , immunology , immune system , genetics , ecology

Studies of varicella-zoster virus (VZV) tropism for T cells support their role in viral transport to the skin during primary infection. Multiparametric single-cell mass cytometry demonstrates that, instead of preferentially infecting skin-homing T cells, VZV alters cell signaling and remodels surface proteins to enhance T cell skin trafficking. Viral proteins dispensable in skin, such as that encoded by open reading frame 66, are necessary in T cells. Interference with VZV T cell tropism may offer novel strategies for drug and vaccine design.

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