No Viral Evolution in the Lymph Nodes of Simian Immunodeficiency Virus-Infected Rhesus Macaques during Combined Antiretroviral Therapy | Zendy

Megu Oue | Zendy; Saori Sakabe | Zendy; Mariko Horiike | Zendy; Mika Yasui | Zendy; Tomoyuki Miura | Zendy; Tatsuhiko Igarashi | Zendy

Open Access

No Viral Evolution in the Lymph Nodes of Simian Immunodeficiency Virus-Infected Rhesus Macaques during Combined Antiretroviral Therapy

Author(s) -

Megu Oue,

Saori Sakabe,

Mariko Horiike,

Mika Yasui,

Tomoyuki Miura,

Tatsuhiko Igarashi

Publication year - 2013

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.03367-12

Subject(s) - simian immunodeficiency virus , biology , virology , lentivirus , simian , cart , virus , viral load , lymph , primate , genome , macaque , antiretroviral therapy , viral disease , gene , genetics , medicine , pathology , mechanical engineering , neuroscience , engineering , paleontology

To elucidate the mode of viral persistence in primate lentivirus-infected individuals during combination antiretroviral therapy (cART), four simian immunodeficiency virus 239-infected monkeys were treated with cART for 1 year. The viral env genes prepared from total RNA extracted from the mesenteric lymph nodes collected at the completion of therapy were assessed by single genome amplification. Analyses of nucleotide substitutions and phylogeny revealed no viral evolution during cART.

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