Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens | Zendy

Hanna G. Budayeva | Zendy; Elizabeth A. Rowland | Zendy; Ileana M. Cristea | Zendy

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Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens

Author(s) -

Hanna G. Budayeva,

Elizabeth A. Rowland,

Ileana M. Cristea

Publication year - 2015

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.03220-14

Subject(s) - biology , sirtuin , context (archaeology) , sirtuin 1 , viral infection , virology , computational biology , microbiology and biotechnology , genetics , virus , gene , paleontology , downregulation and upregulation , acetylation

For a number of years, sirtuin enzymes have been appreciated as effective "sensors" of the cellular environment to rapidly transmit information to diverse cellular pathways. Much effort was placed into exploring their roles in human cancers and aging. However, a growing body of literature brings these enzymes to the spotlight in the field of virology. Here, we discuss sirtuin functions in the context of viral infection, which provide regulatory points for therapeutic intervention against pathogens.

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