Open AccessH3 Stalk-Based Chimeric Hemagglutinin Influenza Virus Constructs Protect Mice from H7N9 Challenge
Author(s) -
Florian Krammer,
Irina Margine,
Rong Hai,
Alexander Flood,
Ariana Hirsh,
Vadim Tsvetnitsky,
Dexiang Chen,
Peter Palese
Publication year - 2013
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.03183-13
Subject(s) - hemagglutinin (influenza) , virology , biology , virus , context (archaeology) , influenza a virus , h5n1 genetic structure , outbreak , pandemic , antigenic drift , covid-19 , medicine , infectious disease (medical specialty) , disease , paleontology , pathology
The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge in the context of different administration routes as well as with a generic oil-in-water adjuvant similar to formulations licensed for use in humans.
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