Open AccessMurine Gammaherpesvirus 68 Encodes a Second PML-Modifying Protein
Author(s) -
Jaturong Sewata,
Paul D. Ling
Publication year - 2013
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.03081-13
Subject(s) - biology , viral tegument , promyelocytic leukemia protein , virology , mutant , ribonucleotide reductase , murine leukemia virus , protein subunit , capsid , virus , phenotype , antiviral protein , microbiology and biotechnology , cell culture , acute promyelocytic leukemia , rna , gene , genetics , retinoic acid
The ORF75c tegument protein of murine gammaherpesvirus 68 (MHV68) promotes the degradation of the antiviral promyelocytic leukemia (PML) protein. Surprisingly, MHV68 expressing a degradation-deficient ORF75c replicated in cell culture and in mice similar to the wild-type virus. However, in cells infected with this mutant virus, PML formed novel track-like structures that are induced by ORF61, the viral ribonucleotide reductase large subunit. These findings may explain why ORF75c mutant viruses unable to degrade PML had no demonstrable phenotype after infection.
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