Open AccessFunction of the Respiratory Syncytial Virus Small Hydrophobic Protein
Author(s) -
Sandra Fuentes,
Kim C. Tran,
Priya Luthra,
Michael N. Teng,
Biao He
Publication year - 2007
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02717-06
Subject(s) - biology , paramyxoviridae , virus , virology , recombinant dna , mononegavirales , pneumovirinae , respiratory system , tumor necrosis factor alpha , pneumovirus , immunology , biochemistry , viral disease , anatomy , gene
Respiratory syncytial virus (RSV), a member of theParamyxoviridae family, encodes a small hydrophobic (SH) protein of unknown function. Parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, also encodes an SH protein, which inhibits tumor necrosis factor alpha (TNF-α) signaling. In this study, recombinant PIV5 viruses without their own SH but containing RSV SH (from RSV strain A2 or B1) in its place (PIV5ΔSH-RSV SH) and RSV lacking its own SH (RSVΔSH) were generated and analyzed. The results indicate that the SH protein of RSV has a function similar to that of PIV5 SH and that it can inhibit TNF-α signaling.