Open AccessHuman Serum Amyloid A Protein Inhibits Hepatitis C Virus Entry into Cells
Author(s) -
Zhaohui Cai,
Lei Cai,
Jieyun Jiang,
Kyung-Soo Chang,
Deneys R. van der Westhuyzen,
Guangxiang Luo
Publication year - 2007
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02627-06
Subject(s) - biology , infectivity , hepatitis c virus , opsonin , serum amyloid a , virus , virology , innate immune system , immune system , immunology , viral entry , microbiology and biotechnology , antibody , inflammation , viral replication
Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.