Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells | Zendy

Jinhong Chang | Zendy; JuTao Guo | Zendy; Dong Jiang | Zendy; Haitao Guo | Zendy; John M. Taylor | Zendy; Timothy M. Block | Zendy

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Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells

Author(s) -

Jinhong Chang,

JuTao Guo,

Dong Jiang,

Haitao Guo,

John M. Taylor,

Timothy M. Block

Publication year - 2008

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.02575-07

Subject(s) - biology , hek 293 cells , mir 122 , hepatitis c virus , replicon , virology , viral replication , virus , cell culture , microrna , embryonic stem cell , microbiology and biotechnology , rna interference , rna , gene , genetics , genome

The liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.

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